产品货号：
Z10506
中文名称：
AFAP1L2抗体
英文名称：
Anti-AFAP1L2 Antibody
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-AFAP1L2 Antibody |
| 指标别名 | AFAP1 like protein 2;AFAP1L2;KIAA1914;XB130 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | ELISA,WB,IHC,IF |
| 基因名称 | AFAP1L2 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | AFAP1L2 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human AFAP1L2.The immunogen is located within the last 50 amino acids of AFAP1L2. |
| 计算分子量 | 91kDa |
| 成分 | AFAP1L2 Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | AFAP1L2 Antibody is affinity chromatography purified via peptide column. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 4℃可保存3个月，-20℃可保存1年。 |
| 背景资料 | AFAP1L2,also known as XB130,is structurally similar to actin-filament-associated protein (AFAP),containing several SH2- and SH3-binding motifs,two pleckstrin homology domains,a coiled-coil region,and many potential phosphorylation sites.It interacts with and is phosphorylated by c-Src tyrosine kinase.Suppression of AFAP1L2 via siRNA reduced Src activity,IL-8 production,EGF-induced phosphorylation of Akt and GSK3beta,and altered cell cycles in human lung epithelial cells suggesting that AFAP1L2 plays a role as an adaptor in the regulation of Src signal transduction and multiple cellular functions.Recent experiments have shown that AFAP1L2 is highly expressed in thyroid and is the substrate RET/PTC kinase,a thyroid-specific kinase that plays a pathogenic role in papillary thyroid cancer.Down-regulation of AFAP1L2 in these cancer cells reduced Akt activity,inhibiting cell-cycle progression and cancer cell survival in suspension,indicating that AFAP1L2 may be a valuable target in thyroid cancer therapy.At least four isoforms of AFAP1L2 are known to exist. |
| Uniprot ID | Q8N4X5 |
| 基因名全称 | Actin filament associated protein 1-like 2 |
| 蛋白名全称 | Actin filament associated protein 1-like 2 |
| 推荐稀释比 | AFAP1L2 antibody can be used for detection of AFAP1L2 by Western blot at 1 ～ 2μg/mL.Antibody can also be used for immunohistochemistry starting at 2.5μg/mL.For immunofluorescence start at 20μg/mL.Antibody validated:Western Blot in mouse samples;Immunohistochemistry in human samples and Immunofluorescence in human samples.All other applications and species not yet tested. |
相关搜索：AFAP1L2抗体，AFAP1L2多抗，Anti-AFAP1L2 Antibody